ea0021p158 | Diabetes and metabolism | SFEBES2009
Hannan Fadil
, Nesbit M Andrew
, Esapa Chris
, Di Pretoro Simona
, Lyon Mary
, Cox Roger
, Thakker Rajesh
The calcium sensing receptor (CaSR) is a G protein coupled receptor that is expressed in type A intercalated cells of the distal convoluted tubule and cortical collecting ducts, where it is involved in renal proton excretion. We have therefore investigated the Nuf mouse, which has an activating CaSR mutation (Leu723Gln) that leads to hypocalcaemia, hypercalciuria, renal calcification, a urinary concentrating defect, and cataracts, for disturbances in acid-base homeostasis. Mic...